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Presented by Dr. Andres Matoso and prepared by Dr. Sintawat Wangsiricharoen.
Adult male with paratesticular mass.
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Question 1 of 1
1. Question
Case 1. Adult male with paratesticular mass.
Correct
Correct: D
Histology: Proliferation of cords of tumor cells forming tubules, with cytoplasmic vacuoles and surrounded by prominent smooth muscle.
Discussion: Adenomatoid tumors present as a scrotal mass and are usually suspected by image studies and therefore frequently excised and submitted for frozen section by the surgeon with the goal to avoid a complete orchiectomy. Tumor cells have bland nuclei with open chromatin and arranged in cords or forming tubules and show intracytoplasmic clear vacuoles. The surrounding stroma often shows prominent smooth muscle differentiation and acquire a more reactive appearance in cases with infarction. While these tumors are most frequently paratesticular, they can occasionally involve testicular parenchyma. By immunohistochemistry, they are positive for mesothelial markers including calretinin and WT1, but are negative for SF1, which can be used in cases difficult to differentiate from Sertoli cell tumors.
References:
Urol Case Rep. 2018 Nov; 21: 34–35.
Int J Clin Exp Pathol. 2015; 8(5): 5914–5918.
Scientific World Journal. 2004; 4: 11–15.Incorrect
Correct: D
Histology: Proliferation of cords of tumor cells forming tubules, with cytoplasmic vacuoles and surrounded by prominent smooth muscle.
Discussion: Adenomatoid tumors present as a scrotal mass and are usually suspected by image studies and therefore frequently excised and submitted for frozen section by the surgeon with the goal to avoid a complete orchiectomy. Tumor cells have bland nuclei with open chromatin and arranged in cords or forming tubules and show intracytoplasmic clear vacuoles. The surrounding stroma often shows prominent smooth muscle differentiation and acquire a more reactive appearance in cases with infarction. While these tumors are most frequently paratesticular, they can occasionally involve testicular parenchyma. By immunohistochemistry, they are positive for mesothelial markers including calretinin and WT1, but are negative for SF1, which can be used in cases difficult to differentiate from Sertoli cell tumors.
References:
Urol Case Rep. 2018 Nov; 21: 34–35.
Int J Clin Exp Pathol. 2015; 8(5): 5914–5918.
Scientific World Journal. 2004; 4: 11–15.
