Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Jonathan Epstein, M.D. and prepared by Orin Buetens, M.D.
Case 2: 26 year old female with an arm mass
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Week 6: Case 2
26 year old female with an arm mass
Correct
Answer: Synovial sarcoma
Histology: The lesion is biphasic consisting of numerous glands set in a stroma with variable cellularity. The glands vary from small and crowded to large and cystically dilated. At higher magnification, the glands consist of cells with high nuclear to cytoplasmic ratios and moderate pleomorphism. In the cellular areas of the stroma the cells in some respects resemble those seen within the glandular component. The cellular areas have a very blue appearance with short spindled fascicles having a high nuclear to cytoplasmic ratio. Mitoses are not frequent. Although such a prominent glandular component is unusual in synovial sarcomas, this histology can be nothing else given the presence of a malignant epithelial and spindle cell biphasic tumor occurring in the soft tissue.
Discussion: Metastatic carcinoma would consist only of a malignant glandular component without malignant spindle cells. Endometriosis would show more benign glandular patterns with cuffing by cellular but totally benign stroma. Epithelioid sarcoma bears no resemblance to synovial sarcoma. Epithelioid sarcoma lacks well formed glands but rather consists of cells ranging from rounded to spindled growing in nodules.
Incorrect
Answer: Synovial sarcoma
Histology: The lesion is biphasic consisting of numerous glands set in a stroma with variable cellularity. The glands vary from small and crowded to large and cystically dilated. At higher magnification, the glands consist of cells with high nuclear to cytoplasmic ratios and moderate pleomorphism. In the cellular areas of the stroma the cells in some respects resemble those seen within the glandular component. The cellular areas have a very blue appearance with short spindled fascicles having a high nuclear to cytoplasmic ratio. Mitoses are not frequent. Although such a prominent glandular component is unusual in synovial sarcomas, this histology can be nothing else given the presence of a malignant epithelial and spindle cell biphasic tumor occurring in the soft tissue.
Discussion: Metastatic carcinoma would consist only of a malignant glandular component without malignant spindle cells. Endometriosis would show more benign glandular patterns with cuffing by cellular but totally benign stroma. Epithelioid sarcoma bears no resemblance to synovial sarcoma. Epithelioid sarcoma lacks well formed glands but rather consists of cells ranging from rounded to spindled growing in nodules.
