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Presented by Peter Illei, M.D. and prepared by Shiyama Mudali, M.D.
Case 6: 81 y.o. woman with abdominal pain.
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Question 1 of 1
1. Question
Week 453: Case 6
81 y.o. woman with abdominal pain. Imaging studies shows enlarged pelvic lymph nodes that were biopsiedimages/1alex/100410case6image1.jpg
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images/1alex/100410case6image5.jpgCorrect
Answer: Metastatic malignant melanoma
Histology: Sections show a core biopsy of dense fibrous tissue with chronic inflammation and clusters of loosely cohesive tumor cells that have plasmacytoid features. A focus of necrotic tumor cells is also noted at one end of the core.
Discussion: Immunostains performed in our laboratory demonstrated that the tumor cells are S-100, Melan-A and MITF positive and HMB45, AE1/AE3, Cam5.2, CK7, CK20, p63 and PAX-8 negative. This staining pattern supports the diagnosis of metastatic melanoma.
Incorrect
Answer: Metastatic malignant melanoma
Histology: Sections show a core biopsy of dense fibrous tissue with chronic inflammation and clusters of loosely cohesive tumor cells that have plasmacytoid features. A focus of necrotic tumor cells is also noted at one end of the core.
Discussion: Immunostains performed in our laboratory demonstrated that the tumor cells are S-100, Melan-A and MITF positive and HMB45, AE1/AE3, Cam5.2, CK7, CK20, p63 and PAX-8 negative. This staining pattern supports the diagnosis of metastatic melanoma.
