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Presented by Hind Nassar, M.D. and prepared by Rui Zheng, M.D., Ph.D.
Case 4: 66 year old woman with a breast mass.
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1. Question
Week 445: Case 4
66 year old woman with a breast massimages/1alex/08022010case4image1.jpg
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images/1alex/08022010case4image5.jpgCorrect
Answer: Displaced benign epithelial cells adjacent to papilloma
Histology: none provided
Discussion: The lesion shows a papilloma with sclerosis and no evidence of atypia. It is adjacent to a biopsy tract. Within the biopsy tract, there a small clusters of epithelial cells; the latter are confined to the biopsy site. These represent displaced epithelial cells from the papilloma due to a previous core biopsy. In some cases the displaced cells lack myoepithelial cells (as demonstrated by immunostains), in this case one should be cautious not to interpret them as invasive carcinoma.
Incorrect
Answer: Displaced benign epithelial cells adjacent to papilloma
Histology: none provided
Discussion: The lesion shows a papilloma with sclerosis and no evidence of atypia. It is adjacent to a biopsy tract. Within the biopsy tract, there a small clusters of epithelial cells; the latter are confined to the biopsy site. These represent displaced epithelial cells from the papilloma due to a previous core biopsy. In some cases the displaced cells lack myoepithelial cells (as demonstrated by immunostains), in this case one should be cautious not to interpret them as invasive carcinoma.
