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Presented by Hind Nassar, M.D. and prepared by Alex Chang, M.D.
Case 5: Excisional biopsy from a 39 year old woman with a breast mass.
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1. Question
Week 419: Case 5
Excisional biopsy from a 39 year old woman with a breast mass.
Correct
Answer: Invasive tubular carcinoma with Columnar cell lesion
Histology: none provided
Discussion: The lesion is composed of tubules with an infiltrative pattern in a background of columnar cell hyperplasia with atypia. The majority of tubular carcinomas (TC, 93%) arise in a background of columnar cell lesions (CCL). Atypical lobular hyperplasia can also be associated with both lesions, TC and CCL (Rosen’s triad).
Incorrect
Answer: Invasive tubular carcinoma with Columnar cell lesion
Histology: none provided
Discussion: The lesion is composed of tubules with an infiltrative pattern in a background of columnar cell hyperplasia with atypia. The majority of tubular carcinomas (TC, 93%) arise in a background of columnar cell lesions (CCL). Atypical lobular hyperplasia can also be associated with both lesions, TC and CCL (Rosen’s triad).
