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Presented by Hind Nassar, M.D. and prepared by Alex Chang, M.D.
Case 3: Core biopsy of the breast performed for a mass on a 55 year old woman.
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1. Question
Week 419: Case 3
Core biopsy of the breast performed for a mass on a 55 year old woman.
Correct
Answer: Sclerosing adenosis with Prominent myoepithelial cells
Histology: none provided
Discussion: Many benign lesions in the breast, including sclerosing adenosis can mimic malignant entities on mammography as well as morphologically. Myoepithelial markers are usually helpful in making the correct diagnosis in cases of sclerosing adenosis. In this case the lesion has a pattern of sclerosing adenosis with “pink” prominent cells. These cells were positive for S100 (which raised the question of a granular cell tumor) but they also stained for p63 and SMM-HC confirming their myoepithelial nature.
Incorrect
Answer: Sclerosing adenosis with Prominent myoepithelial cells
Histology: none provided
Discussion: Many benign lesions in the breast, including sclerosing adenosis can mimic malignant entities on mammography as well as morphologically. Myoepithelial markers are usually helpful in making the correct diagnosis in cases of sclerosing adenosis. In this case the lesion has a pattern of sclerosing adenosis with “pink” prominent cells. These cells were positive for S100 (which raised the question of a granular cell tumor) but they also stained for p63 and SMM-HC confirming their myoepithelial nature.
