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Presented by George Netto, M.D. and prepared by Aatur Singhi, M.D., Ph.D.
Case 2: A 47 year old female presented with lower extremity weakness.
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Question 1 of 1
1. Question
Week 415: Case 2
A 47 year old female presented with lower extremity weakness. A spinal cord mass was present on MRI.images/1alex/11092009case2image1.jpg
images/1alex/11092009case2image2.jpg
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images/1alex/11092009case2image4.jpgCorrect
Answer: Myxopapillary ependymoma
Histology: none provided
Discussion: Myxopapillary Ependymomas occur primarily in adults and affecting the lumbar region of the spinal cord (conus medullaris) leading to compression related symptoms. The less common Myxopapillary Ependymoma occurring intracranially or in the presacral region can be more difficult to diagnose. Their characteristic morphologic features include a richly myxoid stroma leading to a “pseudopapillary” architecture. Epithelioid cells line the latter structures with central vascular structures. Peculiar “balloon” structures composed of collagen rich stroma are occasionally encountered, staining positive for PAS, Alcian Blue and Masson’s trichrome. Myxopapillary Ependymoma are positive for GFAP and S100.
Reference(s):
– PC Burger, BW Scheithauer and FS Vogel. Surgical Pathology of the Nervous System and its Covering. Fourth Edition.Incorrect
Answer: Myxopapillary ependymoma
Histology: none provided
Discussion: Myxopapillary Ependymomas occur primarily in adults and affecting the lumbar region of the spinal cord (conus medullaris) leading to compression related symptoms. The less common Myxopapillary Ependymoma occurring intracranially or in the presacral region can be more difficult to diagnose. Their characteristic morphologic features include a richly myxoid stroma leading to a “pseudopapillary” architecture. Epithelioid cells line the latter structures with central vascular structures. Peculiar “balloon” structures composed of collagen rich stroma are occasionally encountered, staining positive for PAS, Alcian Blue and Masson’s trichrome. Myxopapillary Ependymoma are positive for GFAP and S100.
Reference(s):
– PC Burger, BW Scheithauer and FS Vogel. Surgical Pathology of the Nervous System and its Covering. Fourth Edition.
