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Presented by George Netto, M.D. and prepared by Amy Duffield, M.D., Ph.D.
Case 2: A 36 year old male, presented with cough and hemoptysis.
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Question 1 of 1
1. Question
Week 377: Case 2
A 36 year old male, presented with cough and hemoptysis. He was found to have a 3 CM central lung mass. A transbronchial biopsy was obtained.images/01_05_2009 2A.jpg
images/01_05_2009 2B.jpg
images/01_05_2009 2C.jpg
images/01_05_2009 2D.jpg
images/01_05_2009 2E.jpgCorrect
Answer: Adenoid cystic carcinoma (ACC)
Histology: The mass consists of tumor cells arranged in predominantly tubular and cribriform growth patterns. The tubules are lined by two to three cell layers; the cribriform pattern shows “punched-out” spaces containing eosinophilic or basophilic material. The neoplastic cells are uniform and small with scant cytoplasm and dark, hyperchromatic nuclei and rare mitoses.
Discussion:
Reference(s):
– Devlin, JG and Langer, CJ. Primary adenoid cystic carcinoma of the lung. In Textbook of Uncommon Cancer, third ed. John Wiley and sons, 2006: 321-328.
– Macarenco, RS, et al. Salivary gland-type lung carcinomas: an EGFR immunohistochemical, molecular genetic and mutational analysis study. Mod Pathol 2008; 21, 1168-1175.
– Aubry MC, et al. Primary adenoid cystic carcinoma of lung; absence of KIT mutations. Cancer 2007; 110, 2507-2510.
– Co-author: Hillary Elwood, M.D.Incorrect
Answer: Adenoid cystic carcinoma (ACC)
Histology: The mass consists of tumor cells arranged in predominantly tubular and cribriform growth patterns. The tubules are lined by two to three cell layers; the cribriform pattern shows “punched-out” spaces containing eosinophilic or basophilic material. The neoplastic cells are uniform and small with scant cytoplasm and dark, hyperchromatic nuclei and rare mitoses.
Discussion:
Reference(s):
– Devlin, JG and Langer, CJ. Primary adenoid cystic carcinoma of the lung. In Textbook of Uncommon Cancer, third ed. John Wiley and sons, 2006: 321-328.
– Macarenco, RS, et al. Salivary gland-type lung carcinomas: an EGFR immunohistochemical, molecular genetic and mutational analysis study. Mod Pathol 2008; 21, 1168-1175.
– Aubry MC, et al. Primary adenoid cystic carcinoma of lung; absence of KIT mutations. Cancer 2007; 110, 2507-2510.
– Co-author: Hillary Elwood, M.D.
