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Presented by Peter Illei, M.D. and prepared by Amy Duffield, M.D., Ph.D.
Case 3: 63 y.o. woman with a 2.5 cm left lateral tongue lesion.
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1. Question
Week 376: Case 3
63 y.o. woman with a 2.5 cm left lateral tongue lesionimages/12_15_08 3A.jpg
images/12_15_08 3B.jpg
images/12_15_08 3C.jpg
images/12_15_08 3D.jpg
images/12_15_08 3E.jpgCorrect
Answer: Adenosquamous carcinoma of tongue
Histology: The superficial component is well differentiated and has an exophytic growth pattern that resembles a verrucous carcinoma, whereas the infiltrating component is a moderately differentiated squamous cell carcinoma with extensive tubule/duct formation. Mucin stains mucicarmine and alcian-blue/PAS) show focal intraluminal mucin positivity. Immunostain for p63 shows diffuse nuclear labeling of both superficial and invasive squamous components and partial, basally oriented staining of the ductal component. This staining pattern supports the diagnosis.
Discussion: Primary adenosquamous carcinoma of the tongue is rare. These tumors typically involve the lateral tongue and have a superficial squamous component and deep glandular component.
Incorrect
Answer: Adenosquamous carcinoma of tongue
Histology: The superficial component is well differentiated and has an exophytic growth pattern that resembles a verrucous carcinoma, whereas the infiltrating component is a moderately differentiated squamous cell carcinoma with extensive tubule/duct formation. Mucin stains mucicarmine and alcian-blue/PAS) show focal intraluminal mucin positivity. Immunostain for p63 shows diffuse nuclear labeling of both superficial and invasive squamous components and partial, basally oriented staining of the ductal component. This staining pattern supports the diagnosis.
Discussion: Primary adenosquamous carcinoma of the tongue is rare. These tumors typically involve the lateral tongue and have a superficial squamous component and deep glandular component.
