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Presented by Edward McCarthy, M.D. and prepared by Anil Parwani, M.D.,Ph.D.
Case 1: A middle-aged man had a soft tissue swelling over his finger.
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1. Question
Week 139: Case 1
A middle-aged man had a soft tissue swelling over his finger. A radiograph demonstrated the soft tissue swelling which contained numerous stippled radiodensities.images/6903case1fig1.jpg
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images/6903case1fig5.jpgCorrect
Answer: Tenosynovial chondroma
Histology: Tenosynovial chondromas are examples of synovial chondrometaplasia identical to that seen inside joints where it is known as synovial chondromatosis. Tenosynovial chondromas develop in the synovial membrane that is part of the tendon sheaths.
The histologic features are identical to that of synovial chondromatosis. Islands of hyaline cartilage with calcification and peripheral ossification are present. The hyaline cartilage may occasionally be cellular, and, rarely, cellular atypia may be present.
Discussion: The lesion is not a chondrosarcoma. First, hyaline cartilage chondrosarcomas rarely develop in soft tissue. When they do, they are high-grade lesions with extensive spindle cell differentiation and numerous abnormal mitotic figures. It is safe to assume that mature nodules of hyaline cartilage in the soft tissues are almost always examples of synovial chondrometaplasia.
The lesion is not a periosteal chondroma. Periosteal chondromas are tightly adherent to the bone, often producing scalloped erosions. This current lesion is entirely in the soft tissue.
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Answer: Tenosynovial chondroma
Histology: Tenosynovial chondromas are examples of synovial chondrometaplasia identical to that seen inside joints where it is known as synovial chondromatosis. Tenosynovial chondromas develop in the synovial membrane that is part of the tendon sheaths.
The histologic features are identical to that of synovial chondromatosis. Islands of hyaline cartilage with calcification and peripheral ossification are present. The hyaline cartilage may occasionally be cellular, and, rarely, cellular atypia may be present.
Discussion: The lesion is not a chondrosarcoma. First, hyaline cartilage chondrosarcomas rarely develop in soft tissue. When they do, they are high-grade lesions with extensive spindle cell differentiation and numerous abnormal mitotic figures. It is safe to assume that mature nodules of hyaline cartilage in the soft tissues are almost always examples of synovial chondrometaplasia.
The lesion is not a periosteal chondroma. Periosteal chondromas are tightly adherent to the bone, often producing scalloped erosions. This current lesion is entirely in the soft tissue.