Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Ralph Hruban, M.D. and prepared by Shiyama Mudali, M.D.
Case 1: This 50 some year old patient was found to have an asymptomatic mass in the tail of his pancreas.
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Week 457: Case 1
This 50 some year old patient was found to have an asymptomatic mass in the tail of his pancreas. The lesion was resected and had a mitotic count of 5 mitoses per 10 hpf and a Ki-67 labeling of 8%.images/1alex/110110case1image1.jpg
images/1alex/110110case1image2.jpg
images/1alex/110110case1image3.jpg
images/1alex/110110case1image4.jpg
images/1alex/110110case1image5.jpgCorrect
Answer: Neuroendocrine tumor grade 2
Histology: This neoplasm has the typical appearance of a well-differentiated pancreatic endocrine neoplasm, with uniform round nuclei and a “salt and pepper”chromatin. As noted, the mitotic count was 5 mitoses per 10 hpf and the Ki-67 labeling rate was 8%.
Discussion: The new WHO “blue book” is out and non-syndromic neuroendocrine neoplasms of the pancreas are broadly divided into three grades:
A) Neuroendocrine tumor grade 1 is defined as having 0-1 mitoses per 10 hpf and a Ki-67 labeling rate of 0-2%.
B) Neuroendocrine tumor grade 2 is defined as having 2-20 mitoses per 10 hpf and a Ki-67 labeling rate of 3-20%.
C) Neuroendocrine carcinoma has >20mitoses per 10 hpf and a Ki-67 labeling rate of >20%. This tumor had a mitotic count of 5 mitoses per 10 hpf and a Ki-67 labeling rate of 8%, putting it in the neuroendocrine tumor grade 2.Incorrect
Answer: Neuroendocrine tumor grade 2
Histology: This neoplasm has the typical appearance of a well-differentiated pancreatic endocrine neoplasm, with uniform round nuclei and a “salt and pepper”chromatin. As noted, the mitotic count was 5 mitoses per 10 hpf and the Ki-67 labeling rate was 8%.
Discussion: The new WHO “blue book” is out and non-syndromic neuroendocrine neoplasms of the pancreas are broadly divided into three grades:
A) Neuroendocrine tumor grade 1 is defined as having 0-1 mitoses per 10 hpf and a Ki-67 labeling rate of 0-2%.
B) Neuroendocrine tumor grade 2 is defined as having 2-20 mitoses per 10 hpf and a Ki-67 labeling rate of 3-20%.
C) Neuroendocrine carcinoma has >20mitoses per 10 hpf and a Ki-67 labeling rate of >20%. This tumor had a mitotic count of 5 mitoses per 10 hpf and a Ki-67 labeling rate of 8%, putting it in the neuroendocrine tumor grade 2.
