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Presented by Hind Nassar, M.D. and prepared by Rui Zheng, M.D., Ph.D.
Case 5: 25 year old woman with a neck mass.
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Question 1 of 1
1. Question
Week 445: Case 5
25 year old woman with a neck massimages/1alex/08022010case5image1.jpg
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images/1alex/08022010case5image4.jpgCorrect
Answer: Rosai-Dorfman disease
Histology: none provided
Discussion: The lesion shows an intrasinus histiocytic proliferation with cells displaying emperipolesis or lymphophagocytosis. This feature is characteristic of Rosai-Dorfman disease. Usually it presents with cervical masses by involvement of lymph nodes, however it can occur in any location. In some cases it can be associated with auto-immune disorders. The most common course of the disease is a spontaneous regression.
Incorrect
Answer: Rosai-Dorfman disease
Histology: none provided
Discussion: The lesion shows an intrasinus histiocytic proliferation with cells displaying emperipolesis or lymphophagocytosis. This feature is characteristic of Rosai-Dorfman disease. Usually it presents with cervical masses by involvement of lymph nodes, however it can occur in any location. In some cases it can be associated with auto-immune disorders. The most common course of the disease is a spontaneous regression.
