Journal Club

The Program for microRNA Biology has a monthly journal club where we explore timely microRNA manuscripts with provocative data. The journal club began in 2013 and has attracted a robust audience of faculty and trainees covering a range of miRNA processes.

The journal club is held at noon in the Miller Research Building (MRB) in room 801 on the second Wednesday of the month.  Please contact Marc Halushka ( to get on our mailing list.

The February manuscript is Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response by Sahraei M et al. J Clin Inv 2019.  The discussion is led by Shawn Lupold.

At all of our journal clubs, lunch will be served.  Please bring your own beverage.

Previous Manuscripts

The biochemical basis of microRNA targeting efficacy by McGeary SE et al. Science, 2019

Temporal dynamics of miRNAs in human DLPFC and its association with miRNA dysregulation in schizophrenia. by Hu Z et al. Transl Psychiatry, 2019

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs. by Gabisonia K et al. Nature, 2019

MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis.  Pons-Espinal et al. Stem Cell Reports, 2019

Spring is in the air: seasonal profiles indicate vernal change of miRNA activity. Ludwig N et al. RNA Biol, 2019

Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics. Coenen-Stass AML et al. RNA Biol, 2019

Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.  Nowakowski TJ et al. Nature Neurosci, 2018

A non-coding function of TYRP1 mRNA promotes melanoma growth. Gilot D. et al. Nat Cell Biol, 2017

6mer seed toxicity in tumor suppressive microRNAs. Gao QQ et al. Nature Comm, 2018

miR-222 isoforms are differentially regulated by type-I interferon.  Nejad C. et al. RNA, 2018

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Piwecka M et al. Science, 2018.

Deep sequencing of circulating exosomal microRNA allows non-invasive glioblastoma diagnosis. Ebrahimkhani et al. Biorxiv, 2018.

Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay. Slutskin. et al. Nat Comm, 2018.

Cell-type specific sequencing of microRNAs from complex animal tissues. Alberti C. et al. Nat Methods, 2018.

A microRNA feedback loop regulates global microRNA abundance during aging. Inuai. et al. RNA,  2018.

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Zhang Y. et al.  2017.

Activity-dependent spatially localized miRNA maturation in neuronal dendrites. Sambandan et al., Science, 2017.

FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer. Orellana et al., Sci Trans Med, 2017.

Dicer and microRNAs protect adult dopamine neurons. Chmielarz et al., Cell Death and Disease, 2017.

An integrated expression atlas of miRNAs and their promoters in human and mouse. de Rie et al., Nature Biotechnol, 2017.

Exosomal microRNA Transfer into Macrophages Mediates Cellular Postconditioning.  de Couto, et al., Circulation, 2017.

Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types. Telonis, et al., NAR, 2017.

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing. Golden, et al., Nature, 2017.

The number of biologically relevant microRNA targets has been largely overestimated. Pinzón, et al., Genome Res, 2017.

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting. Santangelo, et al., Cell Rep, 2016.

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction. Shurtleff MJ et al., eLife, 2016.

Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression. Denzler, et al., Molecular Cell, 2016.

Strand-specific in vivo screen of cancer-associated miRNAs unveils a role for miR-21* in SCC progression. Ge, et al., Nat Cell Biol. 2016.

Argonaute-associated short introns are a novel class of gene regulators. Hansen et al., Nat Commun, 2016.

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes. McKenzie et al., Cell Rep, 2016.

Double-stranded microRNA mimics can induce length- and passenger strand–dependent effects in a cell type–specific manner. Goldgraben et al., RNA, 2016.

Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis. Kim et al., PNAS, 2016.

microRNA Function Is Limited to Cytokine Control in the Acute Response to Virus Infection. Aguado et al., Cell Host Microbe,2015.

Genome-wide annotation of microRNA primary transcript structures reveals novel regulatory mechanisms. Chang et al., Genome Res, 2015.

The human decapping scavenger enzyme DcpS modulates microRNA turnover. Meziane et al., Sci Rep, 2015.

MOV10 and FMRP Regulate AGO2 Association with MicroRNA Recognition Elements. Kenny et al., Cell Reports, 2014.

MicroRNA directly enhances mitochondrial translation during muscle differentiation. Zhang et al., Cell, 2014.

On the availability of microRNA-induced silencing complexes, saturation of microRNA-binding sites and stoichiometry. Mayya and Duchaine, NAR, 2015.

Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines. Tosar et al, NAR, 2015.

Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence. Yang et al., Mol Cell, 2014.

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Londin et al., PNAS, 2015.

In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA. La Rocca et al., PNAS, 2015.

Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets. Kumar et al., BMC Biol, 2014.

Quantitative and stoichiometric analysis of the microRNA content of exosomes. Chevillet et al., PNAS, 2014.

Conserved temporal patterns of microRNA expression in Drosophila support a developmental hourglass model. Ninova et al., Genome Biol Evol, 2014.

Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. Richardson et al., Am J Hum Genet, 2013.

Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Mori et al., Cell, 2014.

MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex. Cheng et al, Dev Cell, 2014.

Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules. Cox et al., RNA. 2013.

Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak et al., Nature 2013.

Natural RNA circles function as efficient microRNA sponges. Hansen et al., Nature 2013.

Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding. Helwak et al., Cell. 2013.

High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries. Mullokandov et al., Nat Methods. 2012.

Plasma processing conditions substantially influence circulating microRNA biomarker levels. Cheng et al., PlosOne, 2013.