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Presented by Dr. Andres Matoso and prepared by Dr. Harsimar Kaur
Adult male with kidney mass.
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1. Question
Adult male with kidney mass.
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Correct: B
Histology: The tumor is composed of irregular nests of tumor cells with keratinization, with invasion of the kidney parenchyma, and surrounded by marked stromal desmoplasia.
Discussion: Primary squamous cell carcinoma of the renal pelvis is extremely rare. Risk factors are chronic inflammation of the renal pelvis, most commonly secondary to stones and chronic urinary infection. For the tumor to be designated as squamous cell carcinoma, it must show squamous differentiation in 100% of the tumor. Most patients present in advanced stage (pT3 or higher) but the prognosis is similar to urothelial carcinoma when compared stage by stage. Prognostic factors include vascular invasion, poorly differentiated histology and size of the tumor.
Reference:
Holmäng S, et al. J Urol. 2007. PMID: 17574059Incorrect
Correct: B
Histology: The tumor is composed of irregular nests of tumor cells with keratinization, with invasion of the kidney parenchyma, and surrounded by marked stromal desmoplasia.
Discussion: Primary squamous cell carcinoma of the renal pelvis is extremely rare. Risk factors are chronic inflammation of the renal pelvis, most commonly secondary to stones and chronic urinary infection. For the tumor to be designated as squamous cell carcinoma, it must show squamous differentiation in 100% of the tumor. Most patients present in advanced stage (pT3 or higher) but the prognosis is similar to urothelial carcinoma when compared stage by stage. Prognostic factors include vascular invasion, poorly differentiated histology and size of the tumor.
Reference:
Holmäng S, et al. J Urol. 2007. PMID: 17574059
