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Presented by Dr. Andres Matoso and prepared by Dr. Yembur Ahmad
This case talks about an adult female with a brain mass.
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Histology: The tumor is composed of solid sheets of medium-sized tumor cells with oval nuclei with delicate chromatin and eosinophilic cytoplasm. There are scattered vacuolar spaces with eosinophilic globules.
Discussion: Secretory meningioma is a variant characterized by the presence of intracellular lumina containing PAS-positive eosinophilic secretions called pseudopsammoma bodies. The pseudopsammoma bodies show immunoreactivity for carcinoembryonic antigen (CEA) which can be used as a serologic biomarker of recurrence. The epithelial cells with vacuoles containing pseudopsammoma bodies are also positive for cytokeratin stain.
References:
Louis DN, et al. J Neurosurg. 1991. PMID:1984492Incorrect
Correct: B
Histology: The tumor is composed of solid sheets of medium-sized tumor cells with oval nuclei with delicate chromatin and eosinophilic cytoplasm. There are scattered vacuolar spaces with eosinophilic globules.
Discussion: Secretory meningioma is a variant characterized by the presence of intracellular lumina containing PAS-positive eosinophilic secretions called pseudopsammoma bodies. The pseudopsammoma bodies show immunoreactivity for carcinoembryonic antigen (CEA) which can be used as a serologic biomarker of recurrence. The epithelial cells with vacuoles containing pseudopsammoma bodies are also positive for cytokeratin stain.
References:
Louis DN, et al. J Neurosurg. 1991. PMID:1984492
