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Presented by Dr. Ashley Cimino-Mathews and prepared by Dr. Harsimar Kaur
A 45 year-old female presents with a breast mass.
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1. Question
A 45 year-old female presents with a breast mass.
Correct
Correct answer: Borderline phyllodes tumor
The lesion consists of biphasic epithelial and stromal components, falling into the diagnostic category of “cellular fibroepithelial neoplasm.” The neoplasm displays an irregular, infiltrative interface with the adjacent benign breast parenchyma; variably cellular stroma with abrupt transition between hypocellular and hypercellular areas; and moderate stromal cell atypia with readily apparent mitotic figures. The lesion lacks atypical mitotic figure, stromal overgrowth, and malignant heterologous elements. This combination of histologic features supports classification as a borderline phyllodes tumor. Phyllodes tumors are fibroepithelial neoplasms of the breast that have cellular stroma and a leaf-like architecture. They are subdivided into the categories of benign, borderline and malignant on the basis of the following features: 1) tumor circumscription, 2) degree and characteristics of stromal cellularity, 3) degree of stromal cell atypia, 4) mitotic activity, 5) and presence of malignant heterologous elements.Incorrect
Correct answer: Borderline phyllodes tumor
The lesion consists of biphasic epithelial and stromal components, falling into the diagnostic category of “cellular fibroepithelial neoplasm.” The neoplasm displays an irregular, infiltrative interface with the adjacent benign breast parenchyma; variably cellular stroma with abrupt transition between hypocellular and hypercellular areas; and moderate stromal cell atypia with readily apparent mitotic figures. The lesion lacks atypical mitotic figure, stromal overgrowth, and malignant heterologous elements. This combination of histologic features supports classification as a borderline phyllodes tumor. Phyllodes tumors are fibroepithelial neoplasms of the breast that have cellular stroma and a leaf-like architecture. They are subdivided into the categories of benign, borderline and malignant on the basis of the following features: 1) tumor circumscription, 2) degree and characteristics of stromal cellularity, 3) degree of stromal cell atypia, 4) mitotic activity, 5) and presence of malignant heterologous elements.
