Presented by Dr. Andres Matoso and prepared by Dr. Yembur Ahmad
1 day old female with alveolar mass
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1. Question
A 1 day old baby girl presents with an alveolar mass. What is the diagnosis?
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Correct Answer: B
Histology: Tumor composed of sheets of large polygonal cells with abundant granular eosinophilic cytoplasm.
Discussion: Granular cell epulis is a congenital lesion seen in the gingiva of newborn infants, almost exclusively girls. While similar to granular cell tumor, the granular cell epulis has a more prominent vasculature and does not induce psudohyperplasia of the overlying squamous epithelium. In contrast to granular cell tumor, granular cell epulis is negative for S100 by immunohistochemistry. The tumor is benign and recurrence is not common even when it is incompletely resected.
Histology: Tumor composed of sheets of large polygonal cells with abundant granular eosinophilic cytoplasm.
Discussion: Granular cell epulis is a congenital lesion seen in the gingiva of newborn infants, almost exclusively girls. While similar to granular cell tumor, the granular cell epulis has a more prominent vasculature and does not induce psudohyperplasia of the overlying squamous epithelium. In contrast to granular cell tumor, granular cell epulis is negative for S100 by immunohistochemistry. The tumor is benign and recurrence is not common even when it is incompletely resected.
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