Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Dr. Argani and prepared by Daniel Miller
Adult patient with posterior neck soft tissue mass
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
This is a 62 year old male with posterior neck mass.
What is the correct diagnosis?
Correct
Answer: B. Spindle cell/pleomorphic lipoma
Histology: This is a well differentiated fatty lesion which demonstrates prominent lipoblasts, characterized by nuclei that are scalloped by cytoplasmic lipid. There are associated bland spindle cells with ropy collagen. The lesion lacks markedly hyperchromatic nuclei within fibrous septa, and is negative for MDM2. Instead it demonstrates diffuse labeling for CD34. These findings are diagnostic of pleomorphic/spindle cell lipoma.
Discussion: Liposarcoma, well differentiated, would label for MDM2 and demonstrate hyperchromatic cells within the septa. Fibrolipoma would lack the lipoblasts of the current case. Giant cell reaction to silicone material can result in appearance that simulates lipoblasts; however, there are no multinucleate giant cells in the current case, and no history of silicone exposure.
Incorrect
Answer: B. Spindle cell/pleomorphic lipoma
Histology: This is a well differentiated fatty lesion which demonstrates prominent lipoblasts, characterized by nuclei that are scalloped by cytoplasmic lipid. There are associated bland spindle cells with ropy collagen. The lesion lacks markedly hyperchromatic nuclei within fibrous septa, and is negative for MDM2. Instead it demonstrates diffuse labeling for CD34. These findings are diagnostic of pleomorphic/spindle cell lipoma.
Discussion: Liposarcoma, well differentiated, would label for MDM2 and demonstrate hyperchromatic cells within the septa. Fibrolipoma would lack the lipoblasts of the current case. Giant cell reaction to silicone material can result in appearance that simulates lipoblasts; however, there are no multinucleate giant cells in the current case, and no history of silicone exposure.