Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Dr. Pedram Argani and prepared by Dr. Robert Jones.
Case 3: This is a 64 year old male with an ear canal mass.
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Case 3: This is a 64 year old male with an ear canal mass.
Correct
Answer: B. Ceruminous adenoma
Histologic Description: This is a complex but cytologically bland biphasic neoplasm. While there is extensive sclerosis, one can appreciate biphasic appearance with outer myoepithelial type cells and inner luminal cells. Some of the luminal cells demonstrate the hallmarks of ceruminous epithelium; specifically, eosinophilic cytoplasm with decapitation secretion, and ceroid yellow-brown lipofuscin pigment. These are the typical features of ceruminous adenoma. This lesion, as in this case, typically arises in the outer half of the external auditory canal where the ceruminous sweat glands normally reside.
Differential Diagnosis: Middle ear adenomas have a morphologic appearance resembling tubular carcinoid tumors, and would be expected to label for neuroendocrine markers like chromogranin and synaptophysin. Paragangliomas have nested neuroendocrine type appearance, and would label for neuroendocrine markers but not cytokeratin. Ceruminous adenocarcinomas are defined by greater cytologic atypia, mitosis, and aggressive growth such as perineural invasion.
Reference: Thompson LDR et al Am J Surg Pathol 2004; 28:308-318.Incorrect
Answer: B. Ceruminous adenoma
Histologic Description: This is a complex but cytologically bland biphasic neoplasm. While there is extensive sclerosis, one can appreciate biphasic appearance with outer myoepithelial type cells and inner luminal cells. Some of the luminal cells demonstrate the hallmarks of ceruminous epithelium; specifically, eosinophilic cytoplasm with decapitation secretion, and ceroid yellow-brown lipofuscin pigment. These are the typical features of ceruminous adenoma. This lesion, as in this case, typically arises in the outer half of the external auditory canal where the ceruminous sweat glands normally reside.
Differential Diagnosis: Middle ear adenomas have a morphologic appearance resembling tubular carcinoid tumors, and would be expected to label for neuroendocrine markers like chromogranin and synaptophysin. Paragangliomas have nested neuroendocrine type appearance, and would label for neuroendocrine markers but not cytokeratin. Ceruminous adenocarcinomas are defined by greater cytologic atypia, mitosis, and aggressive growth such as perineural invasion.
Reference: Thompson LDR et al Am J Surg Pathol 2004; 28:308-318.
