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Presented by Ralph Hruban, M.D. and prepared by Anil Parwani, M.D.,Ph.D
Case 3: This adult male presented with a subcutaneous nodule on the side of his face, just anterior to the lower part of his ear.
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1. Question
Week 138: Case 3
This adult male presented with a subcutaneous nodule on the side of his face, just anterior to the lower part of his ear./images/6203case3fig1.jpg
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/images/6203case3fig4.jpgCorrect
Answer: Acinar cell carcinoma
Histology: This neoplasm arose in the salivary gland and was composed of sheets of large polygonal cells with basophilic granular cytoplasm.
Discussion: Acinic cell adenocarcinomas of the salivary gland are malignant epithelial neoplasms which, as the name suggests, show differentiation toward serous acinar cells. Acinic cell adenocarcinomas account for about 20% of all malignant salivary gland tumors. Most arise in the parotid gland. Grossly they can be well-circumscribed, and microscopically, as in this case, they typically are composed of sheets of large polygonal cells with granular basophilic cytoplasm. These neoplasms will immunolabel with antibodies to amylase and variably for cytokeratins.
Incorrect
Answer: Acinar cell carcinoma
Histology: This neoplasm arose in the salivary gland and was composed of sheets of large polygonal cells with basophilic granular cytoplasm.
Discussion: Acinic cell adenocarcinomas of the salivary gland are malignant epithelial neoplasms which, as the name suggests, show differentiation toward serous acinar cells. Acinic cell adenocarcinomas account for about 20% of all malignant salivary gland tumors. Most arise in the parotid gland. Grossly they can be well-circumscribed, and microscopically, as in this case, they typically are composed of sheets of large polygonal cells with granular basophilic cytoplasm. These neoplasms will immunolabel with antibodies to amylase and variably for cytokeratins.
