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Presented by Ralph Hruban, M.D. and prepared by Lynette S. Nichols, M.D.
Case 2: This 50 year old man presented with a pancreatic mass.
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Question 1 of 1
1. Question
Week 106: Case 2
This 50 year old man presented with a pancreatic mass./images/Lyn’s/9-2-02-Hruban-2.a.jpg
/images/Lyn’s/9-2-02-Hruban-2.b.jpg
/images/Lyn’s/9-2-02-Hruban-2.c.jpgCorrect
Answer: Undifferentiated carcinoma with osteoclast-like giant cells
Histology: The neoplasm has three components. Large osteoclast-like giant cells without nuclear atypia, atypical mononuclear cells and an associated intraductal papillary mucinous proliferation.
Discussion: This is another great example of an undifferentiated carcinoma with osteoclast-like giant cells. The large multinucleated giant cells resemble osteoclasts in the bone. As discussed previously, recent molecular evidence has established that these are epithelial neoplasms and the name has therefore recently been changed from “osteoclast-like giant cell tumor” to “undifferentiated carcinoma with osteoclast-like giant cells.” The osteoclast-like giant cells are believed to be non-neoplastic reactive cells.
Incorrect
Answer: Undifferentiated carcinoma with osteoclast-like giant cells
Histology: The neoplasm has three components. Large osteoclast-like giant cells without nuclear atypia, atypical mononuclear cells and an associated intraductal papillary mucinous proliferation.
Discussion: This is another great example of an undifferentiated carcinoma with osteoclast-like giant cells. The large multinucleated giant cells resemble osteoclasts in the bone. As discussed previously, recent molecular evidence has established that these are epithelial neoplasms and the name has therefore recently been changed from “osteoclast-like giant cell tumor” to “undifferentiated carcinoma with osteoclast-like giant cells.” The osteoclast-like giant cells are believed to be non-neoplastic reactive cells.
