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Presented by Ashley Cimino-Mathews, M.D. and prepared by Doreen Nguyen, M.D.
Case 3: A 20 year-old male with an abdominal mass
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1. Question
Week 601: Case 3
A 20 year-old male with an abdominal massimages/d nguyen/10-6-14/case 3/4x_450 pixels.jpg
images/d nguyen/10-6-14/case 3/4x_sclerotic_450 pixels.jpg
images/d nguyen/10-6-14/case 3/10x_necrosis_450 pixels.jpg
images/d nguyen/10-6-14/case 3/20x_450 pixels.jpg
images/d nguyen/10-6-14/case 3/20x_crush_450 pixels.jpgCorrect
Answer: Desmoplastic small round cell tumor
Histology: The biopsy reveals irregular nests of small round blue cells in a fibrous, sclerotic stroma with adjacent adipose tissue and ganglion. The individual cells have high nuclear-to-cytoplasmic ratio, abundant mitoses, some nuclear molding, no real cohesion, and no nucleoli. Immunostains are performed and show the lesional cells to be positive for cytokeratin, desmin and WT1.
Discussion:
Reference(s):
– Lae ME1, Roche PC, Jin L, Lloyd RV, Nascimento AG. Desmoplastic small round cell tumor: a clinicopathologic, immunohistochemical, and molecular study of 32 tumors. Am J Surg Pathol. 2002 Jul;26(7):823-35.Incorrect
Answer: Desmoplastic small round cell tumor
Histology: The biopsy reveals irregular nests of small round blue cells in a fibrous, sclerotic stroma with adjacent adipose tissue and ganglion. The individual cells have high nuclear-to-cytoplasmic ratio, abundant mitoses, some nuclear molding, no real cohesion, and no nucleoli. Immunostains are performed and show the lesional cells to be positive for cytokeratin, desmin and WT1.
Discussion:
Reference(s):
– Lae ME1, Roche PC, Jin L, Lloyd RV, Nascimento AG. Desmoplastic small round cell tumor: a clinicopathologic, immunohistochemical, and molecular study of 32 tumors. Am J Surg Pathol. 2002 Jul;26(7):823-35.
