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Presented by Ralph Hruban, M.D. and prepared by Robert E LeBlanc, M.D.
Case 2: This adult patient presented with a large mass extending from the pancreas to the stomach.
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Question 1 of 1
1. Question
Week 512: Case 2
This adult patient presented with a large mass extending from the pancreas to the stomach. A distal pancreatectomy and partial gastrectomy were performed.images/REL_ONE_2A.jpg
images/REL_ONE_2B.jpg
images/REL_ONE_2C.jpgCorrect
Answer: Schwannoma
Histology: This spindle cell neoplasm also abuts the pancreas. Unlike the case presented above (case 2), this tumor has a lymphoid cuff at the periphery of the tumor. An immunostain for S-100 protein is strongly positive.
Discussion: Schwannomas, as is true in fact for almost all mesenchymal neoplasms, may occasionally abut or even involve the pancreas. In this case, the lymphoid cuff at the periphery of the tumor suggests the diagnosis of a schwannoma, and the diagnosis is supported by the characteristic nuclei and immunolabeling for S-100 protein.
Incorrect
Answer: Schwannoma
Histology: This spindle cell neoplasm also abuts the pancreas. Unlike the case presented above (case 2), this tumor has a lymphoid cuff at the periphery of the tumor. An immunostain for S-100 protein is strongly positive.
Discussion: Schwannomas, as is true in fact for almost all mesenchymal neoplasms, may occasionally abut or even involve the pancreas. In this case, the lymphoid cuff at the periphery of the tumor suggests the diagnosis of a schwannoma, and the diagnosis is supported by the characteristic nuclei and immunolabeling for S-100 protein.
