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Presented by Ralph Hruban, M.D. and prepared by Shiyama Mudali, M.D.
Case 2: This elderly patient was diagnosed with cholelithiasis and cholecystitis.
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Question 1 of 1
1. Question
Week 461: Case 2
This elderly patient was diagnosed with cholelithiasis and cholecystitis. A cholecystectomy was performed.images/1alex/121310case2image1.jpg
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images/1alex/121310case2image5.jpgCorrect
Answer: Chronic cholecystitis
Histology: Although the nuclei are enlarged in this case, they are not Pleomorphic and they have abundant cytoplasm.
Discussion: Reactive epithelial changes in the gallbladder epithelium are common. There can be nuclear hyperchromasia and enlargement, but the reactive cells have a low nuclear to cytoplasm ratio, the architecture is retained, and the changes are usually associated with areas of mucosal injury/denudation. Contrast this case with case 3.
Incorrect
Answer: Chronic cholecystitis
Histology: Although the nuclei are enlarged in this case, they are not Pleomorphic and they have abundant cytoplasm.
Discussion: Reactive epithelial changes in the gallbladder epithelium are common. There can be nuclear hyperchromasia and enlargement, but the reactive cells have a low nuclear to cytoplasm ratio, the architecture is retained, and the changes are usually associated with areas of mucosal injury/denudation. Contrast this case with case 3.
