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Presented by Hind Nassar, M.D. and prepared by Rui Zheng, M.D., Ph.D.]
Case 3: 26 year-old woman with a breast mass.
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1. Question
Week 458: Case 3
26 year-old woman with a breast massimages/1alex/11082010case3image1.jpg
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images/1alex/11082010case3image2.jpgCorrect
Answer: Nodular/cystic hydradenoma
Histology:
Discussion: The tumor forms an intramural nodule within a large cystic space with adjacent breast tissue; there is also adjacent axillary tissue (apocrine sweat glands) indicating a location of the lesion within/close to the axilla. The lesion (nodule) has hyalinized fibrovascular cores with benign clear and eosinophilic cells, some with squamoid features. The morphology is consistent with a nodular/cystic hydradenoma with predominance of clear cells. Intraductal papilloma is usually located in the retro-areolar area and displays 2 cell layers epithelial and myoepithelial cells. Papillary carcinoma displays cytologic atypia.
Incorrect
Answer: Nodular/cystic hydradenoma
Histology:
Discussion: The tumor forms an intramural nodule within a large cystic space with adjacent breast tissue; there is also adjacent axillary tissue (apocrine sweat glands) indicating a location of the lesion within/close to the axilla. The lesion (nodule) has hyalinized fibrovascular cores with benign clear and eosinophilic cells, some with squamoid features. The morphology is consistent with a nodular/cystic hydradenoma with predominance of clear cells. Intraductal papilloma is usually located in the retro-areolar area and displays 2 cell layers epithelial and myoepithelial cells. Papillary carcinoma displays cytologic atypia.
