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Presented by Hind Nassar, M.D. and prepared by Shiyama Mudali, M.D.
Case 5: 27 year old woman with a recurrent neck mass involving the thyroid gland.
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1. Question
Week 450: Case 5
27 year old woman with a recurrent neck mass involving the thyroid gland.images/1alex/09132010case5image1.jpg
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images/1alex/09132010case5image5.jpgCorrect
Answer: Fibromatosis
Histology:
Discussion: This is a bland spindle cell lesion with no evidence of areas of hypercellularity, mitosis or atypia but with an infiltrative pattern into adjacent fat (and thyroid gland, according to history). It shows a delicate vascular pattern. The lesion represents a recurrent fibromatosis. In contrast to sarcomas or sarcomatoid carcinoma the lesion does not show cytologic atypia. In contrast to scar tissue, fibromatosis is more cellular and immunostain for beta-catenin shows a nuclear expression.
Incorrect
Answer: Fibromatosis
Histology:
Discussion: This is a bland spindle cell lesion with no evidence of areas of hypercellularity, mitosis or atypia but with an infiltrative pattern into adjacent fat (and thyroid gland, according to history). It shows a delicate vascular pattern. The lesion represents a recurrent fibromatosis. In contrast to sarcomas or sarcomatoid carcinoma the lesion does not show cytologic atypia. In contrast to scar tissue, fibromatosis is more cellular and immunostain for beta-catenin shows a nuclear expression.
