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Presented by Hind Nassar, M.D. and prepared by Alex Chang, M.D.
Case 1: Core biopsy from a 51 year old woman with an irregular breast mass.
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Question 1 of 1
1. Question
Week 419: Case 1
Core biopsy from a 51 year old woman with an irregular breast mass
Correct
Answer: Fibromatosis
Histology: none provided
Discussion: Fibromatosis is a locally aggressive non-metastasizing lesion that can be primary in the breast or can arise from the chest wall. Microscopically it consists of bland spindle cells arranged in long sweeping fascicles; there is no evidence of atypia or mitotic rate is low. The majority (87%) of the fibromatosis of the breast demonstrate nuclear labeling with beta-catenin. A variety of keratin stains should be performed to rule out metaplastic spindle cell carcinoma.
Incorrect
Answer: Fibromatosis
Histology: none provided
Discussion: Fibromatosis is a locally aggressive non-metastasizing lesion that can be primary in the breast or can arise from the chest wall. Microscopically it consists of bland spindle cells arranged in long sweeping fascicles; there is no evidence of atypia or mitotic rate is low. The majority (87%) of the fibromatosis of the breast demonstrate nuclear labeling with beta-catenin. A variety of keratin stains should be performed to rule out metaplastic spindle cell carcinoma.
