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Presented by George Netto, M.D. and prepared by Aatur Singhi, M.D., Ph.D.
Case 1: A 45 year old female presented with lower extremity weakness.
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Question 1 of 1
1. Question
Week 415: Case 1
A 45 year old female presented with lower extremity weakness. A spinal cord mass was present on MRI.images/1Alex/11092009case1image1.jpg
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images/1Alex/11092009case1image4.jpgCorrect
Answer: Subependymoma
Histology: none provided
Discussion: Subependymoma are well differentiated nodular fibrillar tumors of ependymal origin that primarily affect adults and are regarded as WHO grade I neoplasms. They usually are incidentally found and arise in the lateral or fourth ventricles and can lead to obstruction of CSF flow. Dense calcifications are common on imaging studies.
These flat base firm lesions are typically pauci-cellular with the highly fibrillar background doted by clusters of bland ovoid nuclei. Histologic features can vary by lesional location with the supratentorial lesions showing micocystic architecture with light basophilic content (foramen of Monro located lesions) or more ependymal morphology (fourth ventricle lesions). Subependymoma are GFAP, S100 and Vimentin positive.
Reference(s):
– PC Burger, BW Scheithauer and FS Vogel. Surgical Pathology of the Nervous System and its Covering. Fourth Edition.Incorrect
Answer: Subependymoma
Histology: none provided
Discussion: Subependymoma are well differentiated nodular fibrillar tumors of ependymal origin that primarily affect adults and are regarded as WHO grade I neoplasms. They usually are incidentally found and arise in the lateral or fourth ventricles and can lead to obstruction of CSF flow. Dense calcifications are common on imaging studies.
These flat base firm lesions are typically pauci-cellular with the highly fibrillar background doted by clusters of bland ovoid nuclei. Histologic features can vary by lesional location with the supratentorial lesions showing micocystic architecture with light basophilic content (foramen of Monro located lesions) or more ependymal morphology (fourth ventricle lesions). Subependymoma are GFAP, S100 and Vimentin positive.
Reference(s):
– PC Burger, BW Scheithauer and FS Vogel. Surgical Pathology of the Nervous System and its Covering. Fourth Edition.
