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Presented by Peter Illei, M.D. and prepared by Priya Banerjee, M.D.
Case 6: 36 y.o. female patient with a renal mass.
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Week 371: Case 6
36 y. o. female patient with a renal mass. Core biopsy showed acute inflammation and focal granulomatous inflammation. Tissue cultures were positive for moderate-to-heavy Proteus mirabilis, pan-sensitive to antibiotics except for tetracycline. A nephrectomy was performed.images/11_3_08 xantho_1.jpg
images/11_3_08 xantho_2.jpg
images/11_3_08 xantho_3.jpg
images/11_3_08 xantho_4.jpgCorrect
Answer: Xanthogranulomatous pyelonephritis
Histology: see below
Discussion: Xanthogranulomatous pyelonephritis is a distinct form of chronic infectious pyelonephritis. It is composed of yellow lobulated masses that diffusely replace the parenchyma with partial or complete involvement of the kidney. The condition is usually unilateral and can occur at any age but is most common in the 5th-7th decade. It is more common in women than in men. Urinary obstruction is almost always present. Microscopically, there is a diffuse granulomatous inflammatory infiltrate that includes large numbers of foamy histiocytes and some multinucleated giant cells, lymphocytes, neutrophils and plasma cells. E. coli is the most common etiologic agent but Proteus mirabilis and S. Aureus have also been described.
Incorrect
Answer: Xanthogranulomatous pyelonephritis
Histology: see below
Discussion: Xanthogranulomatous pyelonephritis is a distinct form of chronic infectious pyelonephritis. It is composed of yellow lobulated masses that diffusely replace the parenchyma with partial or complete involvement of the kidney. The condition is usually unilateral and can occur at any age but is most common in the 5th-7th decade. It is more common in women than in men. Urinary obstruction is almost always present. Microscopically, there is a diffuse granulomatous inflammatory infiltrate that includes large numbers of foamy histiocytes and some multinucleated giant cells, lymphocytes, neutrophils and plasma cells. E. coli is the most common etiologic agent but Proteus mirabilis and S. Aureus have also been described.