Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Edward McCarthy, M.D. and prepared by Marc Lewin, M.D.
Case 1: A 28 year old previously healthy woman had pain in the mid-shaft of her lower leg.
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Week 300: Case 1
A 28 year old previously healthy woman had pain in the mid-shaft of her lower leg. A radiograph demonstrated an aggressive destructive lesion in the anterior portion of her mid-tibia. A biopsy was performed./images/2-12-07case1a.jpg
/images/2-12-07case1b.jpg
/images/2-12-07case1c.jpgCorrect
Answer: Adamantinoma
Histology: none provided
Discussion: Adamantinoma is an unusual epithelial neoplasm that occurs primary in bone. It is almost exclusively limited to the mid-portion of the tibia. The epithelial portion is the neoplastic portion and causes bone destruction and may eventually metastasize in 15%-20% of cases.
The lesion is not metastatic carcinoma. Age 28 is a young age for a primary epithelial malignancy to metastasize to bone. While this is a possibility, the mid-shaft of the tibia is an unlikely location. The history of no prior illnesses highly supports the diagnoses of adamantinoma.
The lesion is not a synovial sarcoma. Although like adamantinoma, synovial sarcoma is a connective tissue neoplasm with an epithelial component. However, bone involvement with synovial sarcoma is extremely rare.
The lesion is not osteofibrous dysplasia. Osteofibrous dysplasia is related to adamantinoma and consists of a fibro-epithelial proliferation with rare epithelial cells. The large islands of epithelium indicate adamantinoma. Osteofibrous dysplasia is an intracortical process that does not show extensive bone destruction as in this present case.
Incorrect
Answer: Adamantinoma
Histology: none provided
Discussion: Adamantinoma is an unusual epithelial neoplasm that occurs primary in bone. It is almost exclusively limited to the mid-portion of the tibia. The epithelial portion is the neoplastic portion and causes bone destruction and may eventually metastasize in 15%-20% of cases.
The lesion is not metastatic carcinoma. Age 28 is a young age for a primary epithelial malignancy to metastasize to bone. While this is a possibility, the mid-shaft of the tibia is an unlikely location. The history of no prior illnesses highly supports the diagnoses of adamantinoma.
The lesion is not a synovial sarcoma. Although like adamantinoma, synovial sarcoma is a connective tissue neoplasm with an epithelial component. However, bone involvement with synovial sarcoma is extremely rare.
The lesion is not osteofibrous dysplasia. Osteofibrous dysplasia is related to adamantinoma and consists of a fibro-epithelial proliferation with rare epithelial cells. The large islands of epithelium indicate adamantinoma. Osteofibrous dysplasia is an intracortical process that does not show extensive bone destruction as in this present case.
