Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Matthew F. Georgy, M.D. and prepared by Jeffrey T. Schowinsky, M.D.
Case 1: An 83-year old woman presented with an enlarged para-iliac lymph node.
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Week 289: Case 1
An 83-year old woman presented with an enlarged para-iliac lymph node./images/110606MG1a.jpg
/images/110606MG1b.jpg
/images/110606MG1c.jpg
/images/110606MG1d.jpgCorrect
Answer: Classical Hodgkin lymphoma
Histology: The nodal architecture is effaced by a polymorphous infiltrate. The most striking feature is the presence of numerous epithelioid histiocytes with admixed Langhans-type giant cells. Closer inspection reveals a distinct population of cells with Reed-Sternberg morphology. These cells are positive for CD30 on immunohistochemical studies (not shown).
Discussion: Classical Hodgkin lymphoma (CHL) is a morphologically diverse process that is defined by the presence of Reed-Sternberg (R-S) cells, which are the neoplastic component of the process. The background in most cases of CHL comprises a polymorphous mixture of lymphocytes, plasma cells, eosinophils and histiocytes. In a subset of cases, the histiocytic infiltrate is especially florid and can mimic a granulomatous process such as sarcoidosis. It is therefore important to carefully search for R-S cells before rendering a diagnosis of a benign granulomatous process, especially when the clinical picture is consistent with lymphoma.
Incorrect
Answer: Classical Hodgkin lymphoma
Histology: The nodal architecture is effaced by a polymorphous infiltrate. The most striking feature is the presence of numerous epithelioid histiocytes with admixed Langhans-type giant cells. Closer inspection reveals a distinct population of cells with Reed-Sternberg morphology. These cells are positive for CD30 on immunohistochemical studies (not shown).
Discussion: Classical Hodgkin lymphoma (CHL) is a morphologically diverse process that is defined by the presence of Reed-Sternberg (R-S) cells, which are the neoplastic component of the process. The background in most cases of CHL comprises a polymorphous mixture of lymphocytes, plasma cells, eosinophils and histiocytes. In a subset of cases, the histiocytic infiltrate is especially florid and can mimic a granulomatous process such as sarcoidosis. It is therefore important to carefully search for R-S cells before rendering a diagnosis of a benign granulomatous process, especially when the clinical picture is consistent with lymphoma.
