Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Emily Desantis, MD. and prepared by Kara Judson, M.D.
Case 1: This lesion presented as a tender, firm nodule on the mid-back of a 61 year-old woman.
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Week 265: Case 1
This lesion presented as a tender, firm nodule on the mid-back of a 61 year-old woman. What is your diagnosis?images/4415 case 1 1.jpg
images/4415 case 1 2.jpg
images/4415 case 1 3.jpgCorrect
Answer: Eccrine spiradenoma
Histology: none provided
Discussion: Eccrine spiradenoma typically presents as a solitary, circumscribed intradermal nodule measuring 0.5-5.0cm in diameter. Lesions commonly arise on the upper half of the body and are usually tender or painful. The characteristic histologic appearance demonstrates one or more basophilic tumor nodules within the dermis, with occasional extension into the subcutaneous tissue. The nodules are well circumscribed and are composed of two distinct cell types. At the periphery of the lobules, the cells are small, with round, hyperchromatic nuclei. Toward the center of the lesion, the cells are larger and contain ovoid nuclei with vesicular chromatin and small prominent nucleoli. Ductal differentiation is usually present, and lymphocytes are often seen infiltrating throughout the tumor nodules.
Eccrine spiradenoma is often intensely vascular with large, dilated vascular spaces. For this reason, the low power appearance may resemble an angioma, hemangiopericytoma or a glomus tumor. The histologic differential diagnosis also includes basal cell carcinoma however, in contrast to basal cell carcinoma, eccrine spiradenoma lacks a connection to the overlying epidermis. Additionally, the cytologic features of eccrine spiradenoma are relatively bland, lacking the frequent mitoses and necrosis seen in basal cell carcinoma.Incorrect
Answer: Eccrine spiradenoma
Histology: none provided
Discussion: Eccrine spiradenoma typically presents as a solitary, circumscribed intradermal nodule measuring 0.5-5.0cm in diameter. Lesions commonly arise on the upper half of the body and are usually tender or painful. The characteristic histologic appearance demonstrates one or more basophilic tumor nodules within the dermis, with occasional extension into the subcutaneous tissue. The nodules are well circumscribed and are composed of two distinct cell types. At the periphery of the lobules, the cells are small, with round, hyperchromatic nuclei. Toward the center of the lesion, the cells are larger and contain ovoid nuclei with vesicular chromatin and small prominent nucleoli. Ductal differentiation is usually present, and lymphocytes are often seen infiltrating throughout the tumor nodules.
Eccrine spiradenoma is often intensely vascular with large, dilated vascular spaces. For this reason, the low power appearance may resemble an angioma, hemangiopericytoma or a glomus tumor. The histologic differential diagnosis also includes basal cell carcinoma however, in contrast to basal cell carcinoma, eccrine spiradenoma lacks a connection to the overlying epidermis. Additionally, the cytologic features of eccrine spiradenoma are relatively bland, lacking the frequent mitoses and necrosis seen in basal cell carcinoma.
