Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Pedram Argani, M.D. and prepared by Dengfeng Cao, M.D. Ph.D.
Case 6: 66 year old female with 5.5 cm renal mass.
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Week 227: Case 6
66 year old female with 5.5 cm renal mass./images/DengfengCao/Cao_061205_case6a.jpg
/images/DengfengCao/Cao_061205_case6b.jpg
/images/DengfengCao/Cao_061205_case6c.jpg
/images/DengfengCao/Cao_061205_case6d.jpgCorrect
Answer: Mucinous tubular and spindle carcinoma
Histology: Foci of this tumor has the typical morphology of Mucinous Tubular and Spindle Carcinoma (so-called Henle Loopoma); that is, the tumor is relatively circumscribed, features interconnecting tubular and spindled architecture within a myxoid stroma, and consists of cells with low grade nuclei and eosinophilic cytoplasm. In one area of this tumor, the tubules are prominently collapsed, giving rise to a spindle cell morphology that simulates a sarcoma or sarcomatoid carcinoma. These areas are diffusely immunoreactive for cytokeratin.
Discussion: A sarcomatoid carcinoma would show greater pleomorphism than is seen in the current case. Papillary renal cell carcinoma would typically show more extensive true papillae, and stromal foam cells. Similarly, a high grade collecting duct carcinoma would show greater cytologic atypia, acutely inflamed stroma, and more prominent desmoplasia than the current lesion.
Reference(s):
– Hum Pathol 2001;32:506-512
– Mod Pathol 1999;12:107A.
– World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs, IARC Press, 2004, p.40.Incorrect
Answer: Mucinous tubular and spindle carcinoma
Histology: Foci of this tumor has the typical morphology of Mucinous Tubular and Spindle Carcinoma (so-called Henle Loopoma); that is, the tumor is relatively circumscribed, features interconnecting tubular and spindled architecture within a myxoid stroma, and consists of cells with low grade nuclei and eosinophilic cytoplasm. In one area of this tumor, the tubules are prominently collapsed, giving rise to a spindle cell morphology that simulates a sarcoma or sarcomatoid carcinoma. These areas are diffusely immunoreactive for cytokeratin.
Discussion: A sarcomatoid carcinoma would show greater pleomorphism than is seen in the current case. Papillary renal cell carcinoma would typically show more extensive true papillae, and stromal foam cells. Similarly, a high grade collecting duct carcinoma would show greater cytologic atypia, acutely inflamed stroma, and more prominent desmoplasia than the current lesion.
Reference(s):
– Hum Pathol 2001;32:506-512
– Mod Pathol 1999;12:107A.
– World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs, IARC Press, 2004, p.40.
