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Presented by Ralph Hruban, M.D. and prepared by Maryam Farinola M.D.
Case 6: This elderly patient underwent an exploratory laparotomy for a pancreatic cancer.
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1. Question
Week 219: Case 6
This elderly patient underwent an exploratory laparotomy for a pancreatic cancer. Multiple small nodules were encountered in the liver. One of these nodules was biopsied and submitted for frozen section diagnosis.images/hamartoma 1.jpg
images/hamartoma 2.jpg
images/hamartoma 3.jpg
images/hamartoma 4.jpgCorrect
Answer: Bile duct hamartoma
Histology: The biopsy has three features of note: 1) there are multiple lesions; 2) they contain bile; and 3) they are lined by a flattened epithelium.
Discussion: Bile duct hamartomas (von Myenberg complexes) are potential mimickers of metastatic adenocarcinoma. They have the three features seen in this case: 1) there are multiple lesions; 2) they contain bile; and 3) they are lined by a flattened epithelium.
Bile duct adenomas are usually solitary and they do not contain bile. Pleomorphism and an invasive growth pattern help distinguish adenocarcinomas from bile duct adenomas and hamartomas.
Incorrect
Answer: Bile duct hamartoma
Histology: The biopsy has three features of note: 1) there are multiple lesions; 2) they contain bile; and 3) they are lined by a flattened epithelium.
Discussion: Bile duct hamartomas (von Myenberg complexes) are potential mimickers of metastatic adenocarcinoma. They have the three features seen in this case: 1) there are multiple lesions; 2) they contain bile; and 3) they are lined by a flattened epithelium.
Bile duct adenomas are usually solitary and they do not contain bile. Pleomorphism and an invasive growth pattern help distinguish adenocarcinomas from bile duct adenomas and hamartomas.