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Presented by Dr. Andres Matoso and prepared by Dr. Yembur Ahmad
This case talks about an adult male with a paratesticular mass.
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Histology: Proliferation of tubules, lined with cells with clear cytoplasm and small uniform nuclei.
Discussion: Papillary cystadenoma of the epididymis is a benign neoplasm of the epididymis. The most common clinical presentation is a paratesticular mass or an incidental finding detected during fertility workup. The tumor is composed of cysts and papillae lined with cuboidal or low columnar cells with glycogen-rich clear or vacuolated cytoplasm. There is colloid-like secretion in the cysts. By immunohistochemistry, tumor cells are diffusely positive for CK7 and CAIX shows a cup shape distribution, the same immunophenotype as clear cell papillary renal cell tumor. Papillary cystadenomas of the epididymis are more frequently sporadic and bilateral cases have been associated with vHL disease.
References
Mayo Clin Proc. 2021 Mar;96(3):828-829.
Urology. 2018 Aug;118:189-191.
Am J Surg Pathol. 2014 May;38(5):713-8.Incorrect
Correct: B
Histology: Proliferation of tubules, lined with cells with clear cytoplasm and small uniform nuclei.
Discussion: Papillary cystadenoma of the epididymis is a benign neoplasm of the epididymis. The most common clinical presentation is a paratesticular mass or an incidental finding detected during fertility workup. The tumor is composed of cysts and papillae lined with cuboidal or low columnar cells with glycogen-rich clear or vacuolated cytoplasm. There is colloid-like secretion in the cysts. By immunohistochemistry, tumor cells are diffusely positive for CK7 and CAIX shows a cup shape distribution, the same immunophenotype as clear cell papillary renal cell tumor. Papillary cystadenomas of the epididymis are more frequently sporadic and bilateral cases have been associated with vHL disease.
References
Mayo Clin Proc. 2021 Mar;96(3):828-829.
Urology. 2018 Aug;118:189-191.
Am J Surg Pathol. 2014 May;38(5):713-8.
