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Presented by Dr. Pedram Argani and prepared by Dr. Katelynn Davis
This is a 52 year old male with thigh mass.
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1. Question
This is a 52 year old male with thigh mass.
Correct
Answer: Extraskeletal myxoid chondrosarcoma
Histologic Description: The neoplasm is composed of cords of plump cells with finely vacuolated cytoplasm floating in a myxochondroid matrix in a lace like pattern. The neoplasm was associated with the gene fusion of the EWSR1 and NR4A3 gene.
Differential Diagnosis: Metastatic mucinous adenocarcinoma would be diffusely immunoreactive for cytokeratin, and patients should have a history of such a neoplasm. Myxoid liposarcoma would feature branching papillary vasculature, vacuolated lipoblastic cells, and the characteristic FUS-DDIT3 gene fusion resulting from the t(12;16) translocation. Chordomas are typically midline neoplasms, associated with immunoreactivity for brachyury.
Incorrect
Answer: Extraskeletal myxoid chondrosarcoma
Histologic Description: The neoplasm is composed of cords of plump cells with finely vacuolated cytoplasm floating in a myxochondroid matrix in a lace like pattern. The neoplasm was associated with the gene fusion of the EWSR1 and NR4A3 gene.
Differential Diagnosis: Metastatic mucinous adenocarcinoma would be diffusely immunoreactive for cytokeratin, and patients should have a history of such a neoplasm. Myxoid liposarcoma would feature branching papillary vasculature, vacuolated lipoblastic cells, and the characteristic FUS-DDIT3 gene fusion resulting from the t(12;16) translocation. Chordomas are typically midline neoplasms, associated with immunoreactivity for brachyury.
