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Presented by Dr. Andres Matoso and prepared by Dr. Yembur Ahmad.
45 year old male with a renal mass.
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1. Question
A 45 year old male presents with a renal mass.
Correct
Correct answer: B
Histology: This tumor is composed by a dual population smaller cells surrounded by larger cells with clear or eosinophilic cytoplasm arrange in a nested pattern.
Discussion: 6;11 translocation RCC is a less common type of translocation RCC and has many overlapping morphologic and immunophenotypic features with TFE3 translocation RCC. The classic morphology of t(6;11) RCC is the dual population of smaller cells surrounded by larger cells arranged in a nested pattern as seen in this case. This case also shows prominent melanin pigment. By immunohistochemistry, these tumors are positive for cathepsin-K, HMB45 and Melan -A. While the majority of t(6;11) RCC have a favorable prognosis, recent studies with more aggressive clinical behavior have been reported.
Reference:
Am J Surg Pathol 2017;41:287-298
Am J Surg Pathol 2016;40:1484-1495Incorrect
Correct answer: B
Histology: This tumor is composed by a dual population smaller cells surrounded by larger cells with clear or eosinophilic cytoplasm arrange in a nested pattern.
Discussion: 6;11 translocation RCC is a less common type of translocation RCC and has many overlapping morphologic and immunophenotypic features with TFE3 translocation RCC. The classic morphology of t(6;11) RCC is the dual population of smaller cells surrounded by larger cells arranged in a nested pattern as seen in this case. This case also shows prominent melanin pigment. By immunohistochemistry, these tumors are positive for cathepsin-K, HMB45 and Melan -A. While the majority of t(6;11) RCC have a favorable prognosis, recent studies with more aggressive clinical behavior have been reported.
Reference:
Am J Surg Pathol 2017;41:287-298
Am J Surg Pathol 2016;40:1484-1495
