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Presented by Dr. Fausto Rodriguez and prepared by Daniel Miller
Soft tissue mass in an adult patient.
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Question 1 of 1
1. Question
This neoplasm occurs exclusively in the context of the following disorder:
Correct
Answer: C-Neurofibromatosis type 1
Histology: This large infiltrative mass involving the soft tissues of the calf is characterized by areas of variable cellularity and the presence of pseudomeissnerian corpuscles.
Discussion: The findings supported a diagnosis of massive soft tissue neurofibroma, which occurs exclusively in the setting of NF1. Despite often having areas of increased cellularity, the neoplasm is predominantly low grade, with a low potential for malignant transformation. The caveat is that it may overlie and be associated with a plexiform neurofibroma which does have a higher risk for malignant transformation(1).
Reference:
1. Antonescu CR, Scheithauer BW, Woodruff JM. Tumors of the Peripheral Nervous System. Silver Spring, Maryland: ARP press; 2013.Incorrect
Answer: C-Neurofibromatosis type 1
Histology: This large infiltrative mass involving the soft tissues of the calf is characterized by areas of variable cellularity and the presence of pseudomeissnerian corpuscles.
Discussion: The findings supported a diagnosis of massive soft tissue neurofibroma, which occurs exclusively in the setting of NF1. Despite often having areas of increased cellularity, the neoplasm is predominantly low grade, with a low potential for malignant transformation. The caveat is that it may overlie and be associated with a plexiform neurofibroma which does have a higher risk for malignant transformation(1).
Reference:
1. Antonescu CR, Scheithauer BW, Woodruff JM. Tumors of the Peripheral Nervous System. Silver Spring, Maryland: ARP press; 2013.
