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Presented by Dr. Fausto Rodriguez and prepared by Daniel Miller
A 48 year-old male developed a uniformly enhancing mass involving the left cerebellopontine angle.
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1. Question
A 48 year-old male developed a uniformly enhancing mass involving the left cerebellopontine angle. What is the clinical significance of this morphologic variant?
Correct
Answer: B-Higher risk of recurrence
Histology: Histologic sections demonstrate a bland meningothelial neoplasm with cytoplasmic clearing, and a stroma composed of “blocks” of dense collagen. The findings support a diagnosis of clear cell meningioma.
Discussion: Despite its bland appearance, clear cell meningioma is associated with a higher recurrence rate and is therefore assigned a WHO grade II diagnosis (1).
Reference(s): (if available, if not, do not include)
1. Zorludemir S, Scheithauer BW, Hirose T, et al. Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma. Am J Surg Pathol. 1995;19:493-505.Incorrect
Answer: B-Higher risk of recurrence
Histology: Histologic sections demonstrate a bland meningothelial neoplasm with cytoplasmic clearing, and a stroma composed of “blocks” of dense collagen. The findings support a diagnosis of clear cell meningioma.
Discussion: Despite its bland appearance, clear cell meningioma is associated with a higher recurrence rate and is therefore assigned a WHO grade II diagnosis (1).
Reference(s): (if available, if not, do not include)
1. Zorludemir S, Scheithauer BW, Hirose T, et al. Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma. Am J Surg Pathol. 1995;19:493-505.
