Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Ralph Hruban, M.D. and prepared by Doreen Nguyen, M.D.
Case 2: This 75-year-old man developed back pain.
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Week 561: Case 2
This 75-year-old man developed back pain. After a complex work-up he was found to have a poorly demarcated solid mass in the tail of his pancreas. A distal pancreatectomy was performed.
Correct
Answer: Undifferentiated carcinoma of osteoclast-like giant cells
Histology: This is a touch preparation made from the cut surface of the tumor at the time of intraoperative frozen section consultation. Note the presence of two distinct cell types. Admixed with bizarre cells with large pleomorphic nuclei, are large multi-nucleated cells with multiple uniform small nuclei.
Discussion: In contrast to case 1, the touch preparation from this case revealed clearly neoplastic cells with large pleomorphic nuclei. What was interesting here was the presence of large multi-nucleated cells with multiple uniform small nuclei. These osteoclast-like giant cells are not neoplastic (as demonstrated previously by molecular analyses) and they define the entity.
Reference: Westra WH, Sturm P, Drillenburg P, Choti MA, Klimstra DS, Albores-Saavedra J, Montag A, Offerhaus GJ, Hruban RH. K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.
Reference(s):
– Am J Surg Pathol. 1998 Oct; 22(10):1247-54.Incorrect
Answer: Undifferentiated carcinoma of osteoclast-like giant cells
Histology: This is a touch preparation made from the cut surface of the tumor at the time of intraoperative frozen section consultation. Note the presence of two distinct cell types. Admixed with bizarre cells with large pleomorphic nuclei, are large multi-nucleated cells with multiple uniform small nuclei.
Discussion: In contrast to case 1, the touch preparation from this case revealed clearly neoplastic cells with large pleomorphic nuclei. What was interesting here was the presence of large multi-nucleated cells with multiple uniform small nuclei. These osteoclast-like giant cells are not neoplastic (as demonstrated previously by molecular analyses) and they define the entity.
Reference: Westra WH, Sturm P, Drillenburg P, Choti MA, Klimstra DS, Albores-Saavedra J, Montag A, Offerhaus GJ, Hruban RH. K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.
Reference(s):
– Am J Surg Pathol. 1998 Oct; 22(10):1247-54.
