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Presented by Ralph Hruban, M.D. and prepared by Hillary Ross, M.D.
Case 2: This is a 70 year-old man who developed obstructive jaundice.
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Question 1 of 1
1. Question
Week 489: Case 2
This is a 70 year-old man who developed obstructive jaundice. A Whipple resection was performed.images/1alex/072511case2image2.jpg
images/1alex/072511case2image1.jpgCorrect
Answer: Undifferentiated carcinoma with osteoclast-like giant cells
Histology: This neoplasm had two components: Large non-neoplastic osteoclast-like giant cells admixed with neoplastic mononuclear cells.
Discussion: Undifferentiated carcinoma with osteoclast-like giant cells are epithelial neoplasms with reactive non-neoplastic osteoclast-like giant cells. These neoplasms often arise in association with a more convential gland-forming neoplasm such as an infiltrating adenocarcinoma, a mucinous cystic neoplasm, or pancreatic intraepithelial neoplasia (PanIN).
Reference(s):
– See Westra WH, Sturm P, Drillenburg P, Choti MA, Klimstra DS, Albores-Saavedra J, Montag A, Offerhaus GJ, Hruban RH. Am J Surg Pathol. 1998 Oct;22(10):1247-54Incorrect
Answer: Undifferentiated carcinoma with osteoclast-like giant cells
Histology: This neoplasm had two components: Large non-neoplastic osteoclast-like giant cells admixed with neoplastic mononuclear cells.
Discussion: Undifferentiated carcinoma with osteoclast-like giant cells are epithelial neoplasms with reactive non-neoplastic osteoclast-like giant cells. These neoplasms often arise in association with a more convential gland-forming neoplasm such as an infiltrating adenocarcinoma, a mucinous cystic neoplasm, or pancreatic intraepithelial neoplasia (PanIN).
Reference(s):
– See Westra WH, Sturm P, Drillenburg P, Choti MA, Klimstra DS, Albores-Saavedra J, Montag A, Offerhaus GJ, Hruban RH. Am J Surg Pathol. 1998 Oct;22(10):1247-54
