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Presented by Hind Nassar, M.D. and prepared by Alex Chang, M.D.
Case 5: 62 year old female with a renal mass.
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1. Question
Week 406: Case 5
62 year old female with a renal massimages/1alex/08312009case5image1.jpg
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images/1alex/08312009case5image4.jpgCorrect
Answer: Metanephric adenoma
Histology: none provided
Discussion: Metanephric adenoma is a benign well circumscribed renal neoplasm. The main differential diagnosis includes the solid variant of papillary renal cell carcinoma and epithelial-predominant Wilms tumor. In contrast with metanephric adenoma, papillary renal cell carcinoma labels diffusely with CK7 and EMA; it is WT-1 negative. Wilms tumor and metanephric adenoma are both positive for WT-1 indicating a relation between these 2 tumors. However Wilms tumor displays cytologic atypia, abundant mitotic activity and occurs at a younger age.
Incorrect
Answer: Metanephric adenoma
Histology: none provided
Discussion: Metanephric adenoma is a benign well circumscribed renal neoplasm. The main differential diagnosis includes the solid variant of papillary renal cell carcinoma and epithelial-predominant Wilms tumor. In contrast with metanephric adenoma, papillary renal cell carcinoma labels diffusely with CK7 and EMA; it is WT-1 negative. Wilms tumor and metanephric adenoma are both positive for WT-1 indicating a relation between these 2 tumors. However Wilms tumor displays cytologic atypia, abundant mitotic activity and occurs at a younger age.
