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Presented by George Netto, M.D. & Alcides Chaux, M.D. and prepared by Amy Duffield, M.D., Ph.D.
Case 1: An 18 year old male presented with a penile lesion.
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Question 1 of 1
1. Question
Week 340: Case 1
An 18 year old male presented with a penile lesion./images/1A 2_18_08.jpg
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/images/1E 2_18_08.jpgCorrect
Answer: Granular cell tumor
Histology: none provided
Discussion: Granular Cell Tumor (GCT), formerly named granular cell myoblastoma, has only rarely been reported to involve the penis. Only 18 such occurrences have been reported.
The lesion consists of oval to polygonal shaped cells with abundant coarsely granular cytoplasm, and oval slightly angulated nuclei. The neoplastic cells are arranged in variably sized nests, trabeculae and cords. The associated stroma is usually more collagenous than the native dermal connective tissue. On immunostains, the neoplastic cells show moderate expression of S100 protein.
Granular cell tumors are benign soft tissue neoplasms of probable schwanian cell origin, typically occurring in dermal or subcutaneous tissue of the head and neck region. GCTs, however, have been reported in a wide variety of other sites including visceral locations. GCT can occasionally involve female external genitalia, with the vulva and clitoris being the most common sites of involvement.
Reference(s):
– Laskin WB et al. Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases. Hum Pathol. 2005 Mar;36(3):291-8.Incorrect
Answer: Granular cell tumor
Histology: none provided
Discussion: Granular Cell Tumor (GCT), formerly named granular cell myoblastoma, has only rarely been reported to involve the penis. Only 18 such occurrences have been reported.
The lesion consists of oval to polygonal shaped cells with abundant coarsely granular cytoplasm, and oval slightly angulated nuclei. The neoplastic cells are arranged in variably sized nests, trabeculae and cords. The associated stroma is usually more collagenous than the native dermal connective tissue. On immunostains, the neoplastic cells show moderate expression of S100 protein.
Granular cell tumors are benign soft tissue neoplasms of probable schwanian cell origin, typically occurring in dermal or subcutaneous tissue of the head and neck region. GCTs, however, have been reported in a wide variety of other sites including visceral locations. GCT can occasionally involve female external genitalia, with the vulva and clitoris being the most common sites of involvement.
Reference(s):
– Laskin WB et al. Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases. Hum Pathol. 2005 Mar;36(3):291-8.
