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Presented by Ralph Hruban, M.D. and prepared by Amy Duffield, M.D., Ph.D.
Case 6: This adult patient was imaged for another indication and found to have a solid and cystic pancreatic mass.
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Question 1 of 1
1. Question
Week 329: Case 6
This adult patient was imaged for another indication and found to have a solid and cystic pancreatic mass. The mass was resected./images/6A_10_29_07.jpg
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Answer: Mixed well-differentiated pancreatic endocrine/serous cystic neoplasm
Histology: This neoplasm has two components. Cystic spaces are lined by cuboidal cells with optically clear cytoplasm and uniform round nuclei. The solid component is composed of nests of uniform cells with granular cytoplasm and “salt and pepper” nuclei.
Discussion: As noted in Case 1, mixed well-differentiated pancreatic endocrine/serous cystic neoplasms can arise in patients with the von Hippel-Lindau Syndrome. Mixed well-differentiated pancreatic endocrine/serous cystic neoplasms can also arise sporadically. The prognosis is guided by the endocrine component.
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Answer: Mixed well-differentiated pancreatic endocrine/serous cystic neoplasm
Histology: This neoplasm has two components. Cystic spaces are lined by cuboidal cells with optically clear cytoplasm and uniform round nuclei. The solid component is composed of nests of uniform cells with granular cytoplasm and “salt and pepper” nuclei.
Discussion: As noted in Case 1, mixed well-differentiated pancreatic endocrine/serous cystic neoplasms can arise in patients with the von Hippel-Lindau Syndrome. Mixed well-differentiated pancreatic endocrine/serous cystic neoplasms can also arise sporadically. The prognosis is guided by the endocrine component.
