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Presented by Pedram Argani, M.D. and prepared by Wang (Steve) Cheung, M.D., Ph.D.
Case 4: 20 year old male with a shoulder mass.
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1. Question
Week 322: Case 4
20 year old male with a shoulder mass.images/806074a.jpg
images/806074b.jpg
images/806074c.jpgCorrect
Answer: Hibernoma
Histology: This is a lobulated mass composed of a variety of fat cells. Many have granular-multivacuolated eosinophilic cytoplasm typical of brown fat. Other areas have typical univacuolated fat cells. These are the typical features of a hibernoma.
Discussion: Lipoblastoma typically occurs in infants, and would resemble a myxoid liposarcoma at the periphery of its lobules. Hibernoma may resemble lipoma, but the presence of any brown fat cells in the lesion indicates that it should be classified as a hibernoma. Liposarcoma would feature hyperchromatic, enlarged nuclei of lipoblasts within thickened septa. Hibernomas are benign neoplasms composed of brown fat cells. They typically affect young adults and are most commonly scapular, or interscapular.
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Answer: Hibernoma
Histology: This is a lobulated mass composed of a variety of fat cells. Many have granular-multivacuolated eosinophilic cytoplasm typical of brown fat. Other areas have typical univacuolated fat cells. These are the typical features of a hibernoma.
Discussion: Lipoblastoma typically occurs in infants, and would resemble a myxoid liposarcoma at the periphery of its lobules. Hibernoma may resemble lipoma, but the presence of any brown fat cells in the lesion indicates that it should be classified as a hibernoma. Liposarcoma would feature hyperchromatic, enlarged nuclei of lipoblasts within thickened septa. Hibernomas are benign neoplasms composed of brown fat cells. They typically affect young adults and are most commonly scapular, or interscapular.