Quiz-summary
0 of 1 questions completed
Questions:
- 1
Information
Presented by Pedram Argani, M.D. and prepared by Todd Sheridan, M.D.
Case 3: Fifty-seven year-old female with a 3.5 centimeter anterior mediastinal mass.
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
Results
Time has elapsed
Categories
- Not categorized 0%
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
Week 236: Case 3
Fifty-seven year-old female with a 3.5 centimeter anterior mediastinal mass.images/8.15.05.PAcase3a.jpg
images/8.15.05.PAcase3b.jpg
images/8.15.05.PAcase3c.jpg
images/8.15.05.PAcase3d.jpg
images/8.15.05.PAcase3e.jpgCorrect
Answer: Thymoma
Histology: This is an intrathymic lymphoid-rich lesion. The lesion is fairly well delineated, and has a rounded countour. While the majority of the lesion consists of small lymphocytes, there is a background of thymic epithelial cells that are evenly dispersed throughout the tumor In other parts of this lesion, perivascular serum lakes are identified, as well as areas of medullary differentiation. The normal thymic architecture of cortex and medulla is effaced.
Discussion: Thymic lymphic hyperplasia would retain the normal thymic architecture, and often contains intrathymic lymphoid follicles. Castleman’s Disease is rarely centered in the thymus, and instead affects mediastinal lymph nodes. This lesion is characterized by “onionskinning” of mature lymphoid cells around sclerotic, hypervascular germinal centers. Lymphoblastic Lymphoma typically affects younger patients, and lacks the evenly dispersed epithelial component of a lymphocyte-predominant thymoma. These lesions may have an identical immunophenotype by Flow Cytometry, which is a recognized pitfall.
Incorrect
Answer: Thymoma
Histology: This is an intrathymic lymphoid-rich lesion. The lesion is fairly well delineated, and has a rounded countour. While the majority of the lesion consists of small lymphocytes, there is a background of thymic epithelial cells that are evenly dispersed throughout the tumor In other parts of this lesion, perivascular serum lakes are identified, as well as areas of medullary differentiation. The normal thymic architecture of cortex and medulla is effaced.
Discussion: Thymic lymphic hyperplasia would retain the normal thymic architecture, and often contains intrathymic lymphoid follicles. Castleman’s Disease is rarely centered in the thymus, and instead affects mediastinal lymph nodes. This lesion is characterized by “onionskinning” of mature lymphoid cells around sclerotic, hypervascular germinal centers. Lymphoblastic Lymphoma typically affects younger patients, and lacks the evenly dispersed epithelial component of a lymphocyte-predominant thymoma. These lesions may have an identical immunophenotype by Flow Cytometry, which is a recognized pitfall.