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Presented by Ralph Hruban, M.D. and prepared by Sharon Swierczynski, M.D., Ph.D.
Case 1: This patient presented with abdominal pain and was found to have a 10 cm mass in the lesser sac.
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Question 1 of 1
1. Question
Week 168: Case 1
This patient presented with abdominal pain and was found to have a 10 cm mass in the lesser sac./images/010504case1fig1.jpg
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/images/010504case1fig4.jpgCorrect
Answer: Gastrointestinal stromal tumor
Histology: Despite its unusual location, the lesion shown has the typical histologic appearance of a gastrointestinal stromal tumor. The neoplasm immunolabeled for C-Kit (CD117).
Discussion: Gastrointestinal stromal tumors (GISTs) are neoplasms differentiating along lines similar to those seen in the interstitial cells of Cajal. Although most arise in the stomach (60-70%) or small intestine (20-30%), GISTs have been reported in the omentum and elsewhere. Radiographically and intraoperatively, this GIST appeared to be limited to the lesser sac. The clinical behavior of GISTs can be difficult to predict. Size, mitotic rate, growth pattern, necrosis, and organ of origin are all prognostic indicators.
Reference(s):
J.K. Greenson. Gastrointestinal stromal tumors and other mesenchymal lesions of the gut. Modern Pathology 2003; 16:366-375.Incorrect
Answer: Gastrointestinal stromal tumor
Histology: Despite its unusual location, the lesion shown has the typical histologic appearance of a gastrointestinal stromal tumor. The neoplasm immunolabeled for C-Kit (CD117).
Discussion: Gastrointestinal stromal tumors (GISTs) are neoplasms differentiating along lines similar to those seen in the interstitial cells of Cajal. Although most arise in the stomach (60-70%) or small intestine (20-30%), GISTs have been reported in the omentum and elsewhere. Radiographically and intraoperatively, this GIST appeared to be limited to the lesser sac. The clinical behavior of GISTs can be difficult to predict. Size, mitotic rate, growth pattern, necrosis, and organ of origin are all prognostic indicators.
Reference(s):
J.K. Greenson. Gastrointestinal stromal tumors and other mesenchymal lesions of the gut. Modern Pathology 2003; 16:366-375.
